Background:

The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma. Two transcript variants encoding different isoforms have been found for this gene.

Applications:

WB

Name of antibody:

MET(Phospho-Tyr1003)

Immunogen:

Peptide sequence around phosphorylation site of tyrosine 1003 (V-D-Y(p)-R-A) derived from Human c-Met.

Full name:

MET proto-oncogene, receptor tyrosine kinase

Synonyms：

HGFR; AUTS9; RCCP2; c-Met

SwissProt:

P08581

WB Predicted band size:

156 kDa

WB Positive control:

HepG2 cells lysates

WB Recommended dilution:

500-1000